基于生物信息学探讨骨质疏松症与2型糖尿病的关系

目的：基于生物信息学探讨骨质疏松症与 2 型糖尿病的关系。方法：通过基因表达汇编（GEO）数据库检索骨质疏松症和2型糖尿病的相关数据集,并筛选骨质疏松症-2型糖尿病共同差异表达基因,将数据导入STRING数据库找寻关键基因,以一个单细胞测序数据集作为检验集验证关键基因细胞层面的表达水平,对筛选结果进行基因本体（GO）功能及京都基因与基因组百科全书（KEGG）通路富集分析,并对关键靶点、相关中药进行频数统计及功效分类。结果：骨质疏松症与 2 型糖尿病相关通路集中在 ErbB信号通路、丝活化蛋白激酶（MAPK）信号通路、神经营养素信号通路、NOD样受体信号通路。频数统计结果显示,与骨质疏松症-2型糖尿病关键基因相关的中药有51味,以功效分类,可分为清热解毒药、止痛药、祛风药、补虚药、止呕药。结论：骨质疏松症和2型糖尿病都是复杂的代谢性疾病,涉及众多基因表达网络和信号通路。尽管两种疾病存在复杂的基因网络背景,但是分析结果表明两种疾病之间仍存在高度重合的差异基因表达和信号通路。这表明两种疾病的分子机制密切相关,可能存在共同调控的靶点,因此这些靶点可能成为药物同时干预两种疾病的治疗靶点。     

秦山核电站邻近水域环境化学要素特征

本文根据1989年4、7、10月和1990年1月(春、夏、秋、冬)秦山核电站邻近水域零点生态调查和水质监测结果的资料整理而成。经研究证明,该海域是河-海混合水域,盐度从小于3至12之间变化,受杭州湾的涌潮、风浪的影响,水体混合比较强烈,悬浮颗粒物质的含量比长江口高。由于该测区所处的海岸、海底地形,生态系统、径流输入以及水体交换状况不同,故其海洋学特征也不相同。     

A New Pursuit Mode of Nonlinear Wave Surface

The numerical mode of nonlinear wave transformation based on both the Laplace equation for water field and the Bemoulli equation for water surface is a kind of time-domain boundary problem with initial conditions. And the basis for establishing the numerical mode of nonlinear wave in time domain is to trace the position of wave free surface and to calculale the instantaneous surface height and surface potential function. This paper firstly utilizes the ‘0-1‘ combined BEM to separate the boundary by means of discretization of Green‘ s integral equation based on the Laplace equation, then separates the free surface of wave with FEM and derives the FEM equation of wave surface that satisfies the nonlinear boundary conditions. By jointly solving the above BEM and FEM equations, the wave potential and surface height could be obtained with iteration in time domain. Thus a new kind of nonlinear numerical mode is established for calculating wave transformation. The wave test in the numerical wave tank shows that the numerical simulation with this mode is of high accuracy.     

基于雷达海冰图像互相关的冰漂流场测量

我国的渤海和黄海北部在每年冬季都出现不同程度的冰情,它直接影响结冰海区的石油平台、船舶以及港口等设施的正常作业,对海冰的观测与预报随着上述海区的开发利用越发显得重要,利用航海雷达连续准确地跟踪海冰漂移运动轨迹,是当今观测、调查、研究冰漂流移动规律的有效方法之一,我国的科研人员利用雷达成像技术对渤海的冰情进行了长期的雷达海冰观测、研究,在由雷达海冰图像对海冰的物理特征的识别、分类以及冰漂流场测量方面取得了一些进展[1-4]。     

冬季和春季长江口及其近海水域浮游病毒丰度的分析

采用荧光显微技术,对2006年长江口及近海水域20个站点的表层及10m层或潜水体冬、春两季的浮游病毒丰度进行了检测,对浮游病毒丰度在季节（冬、春两季）、水平分布和垂直分布上的变化进行了探讨.调查区浮游病毒丰度在冬、春季节上并无明显差异,但在水平分布上存在很大差异,河口区浮游病毒直接检测量（Virus Direct Count, VDC）达到10^7个/ml,近海水域VDC为10^6个/ml,河口区的浮游病毒丰度都明显高于近海水域病毒丰度 （P＜0.01）.在垂直分布上,冬、春两季长江口水域水深小于10m的站位,表层浮游病毒丰度与底层病毒丰度无明显差别,水深大于10m的站位,表层水样的浮游病毒丰度都高于10m水层病毒丰度,说明长江口浮游病毒的垂直分布与站位总水深有关.还通过比较各站点VDC与叶绿素a含量的数据,分析了二者之间的相关性：冬季浮游病毒丰度与叶绿素a含量成正相关性;春季浮游病毒丰度与叶绿素a含量成负相关性,但病毒丰度受叶绿素a含量的影响仅为10%-11%.     

Second-order random interfacial wave solutions for two-layer fluid with a free surface

1 Introduction Interfacial waves travelling along the interface between two fluids of different densities can be often observed in subsurface layers of the ocean since the upper subsurface layer is warmer over much of the o- cean (Umeyama, 2002). They are…     

机载雷达高度计对海况及海面风速的测量研究

运用我国自行研制的ＺＨＧ－１型Ｘ波段机载雷达高度计于１９９５年４月１３日－４月１８日在青岛附近海域进行的海上飞行实验数据，及导出的均方根波高、有效波高、均方根波陡算法模型，得到了上述海况参数值。     

苏北盆地中古生代油气勘探发现与生储盖组合特征及现实意义

苏北盆地中古生代油气勘探具有50年的历史,在收集前人资料分析基础上,对苏北盆地和黄桥二氧化碳气田及朱家墩天然气田生储盖体系的地质特征及成藏要素分别进行了对比,分析了典型成藏模式;认为苏北盆地虽然只是苏北—南黄海盆地古、中、新生代盆地的一小部分,但其幔源"古生新储"二氧化碳气田和常规"古生新储"天然气田的发现对于海域南黄海盆地极具现实意义。     

柴达木盆地昆特依盐湖的地球化学演化与古气候变化

１９９０年用铀系年代学及古地磁对昆特依盐湖沉积物进行年代测定，探讨该湖区地球化学演化与古气候变化关系。结果表明，该区最老的盐层形成于早更新世晚期（大于７３０ｋａ），大量的盐类沉积则始于３００ｋａ左右；盐湖沉积物中元素含量变化主要受古盐度、矿物、类质同象和吸附控制；沉积物水溶Ｆ／Ｃｌ比值与古盐度成反比关系；该湖２０００ｋａ以来的古环境演变：盐层形成于干冷、偏酸性的氧化环境，泥岩层形成于湿暖、偏碱性的     

Characteristic analysis on oxygen isotopic tracer in the East China Sea and waters to east of the Ryūkyū-guntō

Samples of O isotopic tracer were mlleMed at Sections P₃,P₂₅,P_cM-t/2-E and P_CM-1/2.w in both the Fast China Sea and the area to the east of the Ryūkyū-gunto during October-November,1991.Analytical results of the δ¹⁸O are as follows: (1) In the Kuroshio area,the δ¹⁸O isolines are almost parallel to the 200 m isobath.The value of δ¹⁸O is negative and reaches minimum mt the main axis of the Kuroshio,and increases on both sides.(2) In the Taiwan Warm Current (TWC) area there is a high δ¹⁸O tongue extending to the northeast.(3) In the area near the coast,the distribution of δ¹⁸O isoline shows that the Changjiang River runoff diffuses seaward and the land-ocean isotopic effect from the nearshore to the offshore.(4) The values of δ¹⁸O are from -1.0×10^-3 to -0.5×10^-3 in the shelf.(5) There is a low mre of δ¹⁸O value(<-1.6×10^-3) at the 600 m layer in the Kuroshio area,which is quite in accord with the existence of a low salinity mre (S G 34.30) between the 600 and 800 m layers in the same area.Finally,the mrrelations of the δ¹⁸O with the salinity and temperature,the upwelling and so on are discussed.